Peptide Epitalon activates chromatin at the old age

Neuro Endocrinol Lett. 2003 Oct;24(5):329-33.


OBJECTIVES and design. We have studied the effect of synthetic peptide Epitalon on the activity of ribosomal genes, denaturation parameters of total heterochromatin, polymorphism of structural C-heterochromatin and the variability of facultative heterochromatin in cultured lymphocytes of persons aged 76-80 years.

Results: The obtained data demonstrate that Epitalon induces the activation of ribosomal genes, decondensation of pericentromeric structural heterochromatin and the release of genes repressed due to the age-related condensation of euchromatic chromosome regions.

Conclusions: Epitalon has shown its ability to activate chromatin by modifying heterochromatin and heterochromatinized chromosome regions in the cells of older persons.

MeSH terms

  • Aged
  • Aging / physiology*
  • Cells, Cultured
  • Euchromatin / drug effects
  • Euchromatin / genetics
  • Heterochromatin / drug effects*
  • Heterochromatin / genetics*
  • Hot Temperature
  • Humans
  • Lymphocytes / cytology
  • Lymphocytes / drug effects
  • Lymphocytes / physiology
  • Oligopeptides / pharmacology*
  • Protein Denaturation
  • Ribosomal Proteins / genetics
  • Transcriptional Activation / drug effects


  • Euchromatin
  • Heterochromatin
  • Oligopeptides
  • Ribosomal Proteins
  • alanyl-glutamyl-aspartyl-glycine