Abstract
The membrane-associated carboxypeptidase angiotensin-converting enzyme 2 (ACE2) is an essential regulator of heart function. Now, Li at al. identify and characterize an unexpected second function of ACE2 as a partner of the SARS-CoV spike glycoprotein in mediating virus entry and cell fusion.
MeSH terms
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Angiotensin-Converting Enzyme 2
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Binding Sites / physiology
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Carboxypeptidases / metabolism*
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Membrane Fusion / physiology
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Peptidyl-Dipeptidase A
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Protein Conformation
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Receptors, Cell Surface / metabolism*
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Severe acute respiratory syndrome-related coronavirus / metabolism*
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Viral Fusion Proteins / metabolism*
Substances
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Receptors, Cell Surface
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Viral Fusion Proteins
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Carboxypeptidases
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Peptidyl-Dipeptidase A
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ACE2 protein, human
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Angiotensin-Converting Enzyme 2