Hyperinsulinaemic hypoglycaemia in preterm neonates

Arch Dis Child Fetal Neonatal Ed. 2004 Jan;89(1):F65-7. doi: 10.1136/fn.89.1.f65.


Hyperinsulinism in infancy (HI) is an important cause of severe and recurrent hypoglycaemia in newborn infants. It usually appears in infants born at term, and only one case of its occurrence in a prematurely born infant has been reported as an incidental finding. This is a report of seven infants born at 31-36 weeks gestation who experienced severe persistent hyperinsulinism. Two infants were large for dates. All infants were difficult to manage, suggesting that the occurrence of HI with prematurity may be associated with a particularly aggressive illness. HI should be considered in the differential diagnosis of severe hypoglycaemia in preterm infants.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Birth Weight
  • Chlorothiazide / therapeutic use
  • Diazoxide / therapeutic use
  • Diuretics
  • Female
  • Glucose / administration & dosage
  • Humans
  • Hyperinsulinism / blood
  • Hyperinsulinism / complications*
  • Hypoglycemia / blood
  • Hypoglycemia / etiology*
  • Hypoglycemia / therapy
  • Infant, Newborn
  • Infant, Premature, Diseases / blood
  • Infant, Premature, Diseases / etiology*
  • Infant, Premature, Diseases / immunology
  • Infant, Premature, Diseases / therapy
  • Male
  • Sodium Chloride Symporter Inhibitors / therapeutic use


  • Diuretics
  • Sodium Chloride Symporter Inhibitors
  • Chlorothiazide
  • Glucose
  • Diazoxide