Tenascin C and cathepsin d expression in adipocytic tumors: an immunohistochemical investigation of 43 cases

Int J Surg Pathol. 2004 Jan;12(1):11-5. doi: 10.1177/106689690401200102.


Cathepsin D (CatD) and tenascin C (Tn-C) have been implicated in invasion and metastasis of carcinomas. However, little is known about CatD and Tn-C distribution in mesenchymal tumors. Therefore, we aimed to investigate the expression of Tn-C and CatD in adipocytic tumors. Tn-C and CatD expressions in 27 lipomas, 5 atypical lipomatous tumor/well-differentiated liposarcomas (ALT/WDLS) and 11 liposarcomas (LS) were evaluated by immunohistochemistry and scored semiquantitatively. CatD expression was higher in ALT/WDLS than in lipomas (p<0.001), and higher in LS than in ALT/WDLS (p=0.009). Stromal Tn-C expression was higher in ALT/WDLS than in lipomas (p=0.02), but no difference was observed between ALT/WDLS and LS (p>0.05). These results indicate that Tn-C and CatD may be markers of locally aggressive or malignant behavior in adipocytic tumors.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Biomarkers, Tumor / analysis*
  • Cathepsin D / biosynthesis*
  • Female
  • Humans
  • Immunohistochemistry
  • Lipoma / metabolism
  • Lipoma / pathology
  • Liposarcoma / metabolism
  • Liposarcoma / pathology
  • Male
  • Middle Aged
  • Neoplasms, Adipose Tissue / metabolism*
  • Neoplasms, Adipose Tissue / pathology
  • Prognosis
  • Tenascin / biosynthesis*


  • Biomarkers, Tumor
  • Tenascin
  • Cathepsin D