Use of CD134 as a primary receptor by the feline immunodeficiency virus

Science. 2004 Feb 20;303(5661):1192-5. doi: 10.1126/science.1092124.

Abstract

Feline immunodeficiency virus (FIV) induces a disease similar to acquired immunodeficiency syndrome (AIDS) in cats, yet in contrast to human immunodeficiency virus (HIV), CD4 is not the viral receptor. We identified a primary receptor for FIV as CD134 (OX40), a T cell activation antigen and costimulatory molecule. CD134 expression promotes viral binding and renders cells permissive for viral entry, productive infection, and syncytium formation. Infection is CXCR4-dependent, analogous to infection with X4 strains of HIV. Thus, despite the evolutionary divergence of the feline and human lentiviruses, both viruses use receptors that target the virus to a subset of cells that are pivotal to the acquired immune response.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / metabolism
  • CD4-Positive T-Lymphocytes / virology
  • Cats
  • Cell Line
  • Cell Line, Tumor
  • DNA, Complementary
  • Gene Library
  • HIV / metabolism
  • HeLa Cells
  • Heterocyclic Compounds / pharmacology
  • Humans
  • Immunodeficiency Virus, Feline / metabolism*
  • Immunodeficiency Virus, Feline / pathogenicity
  • Mice
  • Molecular Sequence Data
  • NIH 3T3 Cells
  • Receptors, CXCR4 / antagonists & inhibitors
  • Receptors, CXCR4 / metabolism
  • Receptors, OX40
  • Receptors, Tumor Necrosis Factor / chemistry
  • Receptors, Tumor Necrosis Factor / genetics
  • Receptors, Tumor Necrosis Factor / immunology
  • Receptors, Tumor Necrosis Factor / metabolism*
  • Receptors, Virus / chemistry
  • Receptors, Virus / genetics
  • Receptors, Virus / immunology
  • Receptors, Virus / metabolism*
  • Species Specificity
  • Transduction, Genetic
  • Transfection

Substances

  • DNA, Complementary
  • Heterocyclic Compounds
  • Receptors, CXCR4
  • Receptors, OX40
  • Receptors, Tumor Necrosis Factor
  • Receptors, Virus
  • TNFRSF4 protein, human
  • Tnfrsf4 protein, mouse
  • plerixafor octahydrochloride