Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) is a selective estrogen-response modulator in human breast cancer cells: gamma-linolenic acid antagonizes estrogen receptor-dependent transcriptional activity, transcriptionally represses estrogen receptor expression and synergistically enhances tamoxifen and ICI 182,780 (Faslodex) efficacy in human breast cancer cells

Int J Cancer. 2004 May 10;109(6):949-54. doi: 10.1002/ijc.20096.
No abstract available

Publication types

  • Comparative Study
  • Letter

MeSH terms

  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / genetics
  • Breast Neoplasms / metabolism
  • Drug Synergism
  • Estradiol / analogs & derivatives*
  • Estradiol / therapeutic use
  • Estrogen Receptor Modulators / therapeutic use*
  • Female
  • Fulvestrant
  • Humans
  • Luciferases / metabolism
  • Neoplasms, Hormone-Dependent / drug therapy*
  • Neoplasms, Hormone-Dependent / metabolism
  • Promoter Regions, Genetic / genetics
  • Receptors, Estrogen / drug effects
  • Receptors, Estrogen / metabolism*
  • Tamoxifen / therapeutic use
  • Transcription, Genetic*
  • Tumor Cells, Cultured
  • gamma-Linolenic Acid / pharmacology*

Substances

  • Estrogen Receptor Modulators
  • Receptors, Estrogen
  • Tamoxifen
  • Fulvestrant
  • Estradiol
  • gamma-Linolenic Acid
  • Luciferases