How free fatty acids inhibit glucose utilization in human skeletal muscle

News Physiol Sci. 2004 Jun:19:92-6. doi: 10.1152/nips.01459.2003.


Rat muscle studies suggest competition between free fatty acids (FFA) and glucose for oxidation, resulting in glucose-6-phosphate accumulation. However, FFA decrease glucose-6-phosphate in human skeletal muscle, indicating direct inhibition of glucose transport/phosphorylation. This mechanism could redirect glucose from muscle to brain during fasting and explain the insulin resistance associated with high-lipid diets and obesity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Fatty Acids, Nonesterified / metabolism*
  • Glucose / metabolism*
  • Humans
  • Muscle, Skeletal / metabolism*


  • Fatty Acids, Nonesterified
  • Glucose