Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors

Nat Neurosci. 2004 Jul;7(7):695-6. doi: 10.1038/nn1270. Epub 2004 Jun 20.

Abstract

The basis for differences in activity-dependent trafficking of AMPA receptors (AMPARs) and NMDA receptors (NMDARs) remains unclear. Using single-molecule tracking, we found different lateral mobilities for AMPARs and NMDARs: changes in neuronal activity modified AMPAR but not NMDAR mobility, whereas protein kinase C activation modified both. Differences in mobility were mainly detected for extrasynaptic AMPARs, suggesting that receptor diffusion between synaptic and extrasynaptic domains is involved in plasticity processes.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Antibodies
  • Carbocyanines / pharmacokinetics
  • Cells, Cultured
  • Hippocampus / cytology*
  • Neurons / metabolism*
  • Potassium Chloride / pharmacology
  • Protein Kinase C / antagonists & inhibitors
  • Protein Transport / physiology
  • Rats
  • Receptors, AMPA / metabolism*
  • Receptors, N-Methyl-D-Aspartate / metabolism*
  • Statistics, Nonparametric
  • Synapses / metabolism
  • Tetradecanoylphorbol Acetate / pharmacology
  • Tetrodotoxin / pharmacology
  • Time Factors

Substances

  • Antibodies
  • Carbocyanines
  • NR1 NMDA receptor
  • Receptors, AMPA
  • Receptors, N-Methyl-D-Aspartate
  • cyanine dye 3
  • Tetrodotoxin
  • Potassium Chloride
  • Protein Kinase C
  • Tetradecanoylphorbol Acetate
  • glutamate receptor ionotropic, AMPA 2