Diverse and potent activities of HGF/SF in skin wound repair

J Pathol. 2004 Jul;203(3):831-8. doi: 10.1002/path.1578.


Genetic studies in the mouse have highlighted essential roles for several growth factors in skin repair and have offered a rationale for their use in therapy. The present study shows that the plasminogen-related growth factor HGF/SF (hepatocyte growth factor/scatter factor) promotes wound repair in homozygous diabetic db/db mice by recruiting neutrophils, monocytes, and mast cells to the wound; by promoting the migration of endothelial cells to the injured area; and by enhancing keratinocyte migration and proliferation. As a result, granulation tissue formation, wound angiogenesis, and re-epithelialization are all increased. The results demonstrate that HGF/SF affects and sustains all key cellular processes responsible for wound repair and point to a unique potential of this molecule for the therapy of chronic skin wounds.

MeSH terms

  • Animals
  • Epithelial Cells / drug effects
  • Granulation Tissue / drug effects
  • Hepatocyte Growth Factor / pharmacology*
  • Keratinocytes / drug effects
  • Mast Cells / physiology
  • Mice
  • Monocytes / physiology
  • Neovascularization, Physiologic / drug effects
  • Neutrophil Infiltration / drug effects
  • Skin / blood supply
  • Skin / injuries*
  • Wound Healing / drug effects*
  • Wound Healing / physiology


  • Hepatocyte Growth Factor