Screw loosening is considered to be a common problem with both screw-retained and cemented implant restorations. A wider abutment platform, as well as using a torque driver to tighten specifically designed screws may help prevent this loosening. However, there has been no clinical study evaluating either of these. To longitudinally compare the frequency of screw loosening in standard diameter, (3.75 and 4.0 mm) implant supported prostheses to that of wide diameter, (5.0 and 6.0 mm) implant supported prostheses that were hand tightened, and to evaluate whether using a torque driver would minimize or prevent this problem, if screw loosening occurred. A total of 213 dental implants in 106 patients were included in this prospective longitudinal study. Of the implants 68 were wide diameter and 145 were standard diameter implants. Wide diameter implants showed 5.8% screw loosening, while standard diameter implants showed 14.5% screw loosening after insertion with only hand torquing. When these loose screws were tightened with a torque driver, there was no more loosening of screws. Within the limitations of this study, the wide diameter implants tested showed less screw loosening than the standard diameter implants when hand torqued. Additionally, within the scope of our study, using a torque driver to tighten the screws with the recommended force prevented this loosening from reoccurring in all cases.