Viral hijacking of G-protein-coupled-receptor signalling networks

Nat Rev Mol Cell Biol. 2004 Dec;5(12):998-1012. doi: 10.1038/nrm1529.


Viruses use a surprising diversity of approaches to hijack G-protein-coupled receptors and harness their activated intracellular signalling pathways. All of these approaches ultimately function to ensure viral replicative success and often contribute to their pathogenesis. Indeed, a single virus might deploy a repertoire of these strategies to regulate key intracellular survival, proliferative and chemotactic pathways. Understanding the contribution of these biochemical routes to viral pathogenesis might facilitate the development of effective target-specific therapeutic strategies against viral diseases.

Publication types

  • Review

MeSH terms

  • Apoptosis / physiology
  • Chemokines / metabolism
  • HIV Envelope Protein gp120 / metabolism
  • Humans
  • Models, Biological
  • Receptors, Chemokine / metabolism
  • Receptors, G-Protein-Coupled / metabolism*
  • Second Messenger Systems / physiology*
  • Virus Replication / physiology*
  • Viruses / metabolism*
  • Viruses / pathogenicity


  • Chemokines
  • HIV Envelope Protein gp120
  • Receptors, Chemokine
  • Receptors, G-Protein-Coupled