How are specialized (low-fidelity) eukaryotic polymerases selected and switched with high-fidelity polymerases during translesion DNA synthesis?

DNA Repair (Amst). 2005 Feb 3;4(2):279-83. doi: 10.1016/j.dnarep.2004.08.011.


Specialized DNA polymerases are required in both prokaryotic and eukaryotic cells for bypassing sites of template DNA damage that arrest high-fidelity DNA replication. Recent studies in the literature provide hints of the complexity of DNA switching between polymerases for translesion DNA synthesis (TLS) and those for normal DNA replication.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA Damage*
  • DNA Repair / physiology*
  • DNA Replication / physiology*
  • DNA-Directed DNA Polymerase / physiology*
  • Eukaryotic Cells / physiology
  • Humans
  • SUMO-1 Protein / physiology
  • Ubiquitin / physiology


  • SUMO-1 Protein
  • Ubiquitin
  • DNA-Directed DNA Polymerase