Brain stem glioblastoma with multiple large cyst formation and leptomeningeal dissemination in a 4-year-old girl

Brain Dev. 2005 Jan;27(1):58-61. doi: 10.1016/j.braindev.2004.03.007.

Abstract

The authors report a 4-year-old girl who developed brain stem glioblastoma. Meningeal irritation was present at onset. Magnetic resonance imaging revealed intracranial and intraspinal leptomeningeal dissemination, which progressed faster than the original tumor. Multiple large cysts developed at the interhemispheric and prepontine cisterns, resulting in progressive obstructive hydrocephalus. The patient survived only 5 months after presentation. Histology was verified by autopsy.

Publication types

  • Case Reports

MeSH terms

  • Arachnoid / pathology
  • Arachnoid Cysts / etiology*
  • Arachnoid Cysts / pathology
  • Arachnoid Cysts / physiopathology
  • Brain / pathology
  • Brain Stem Neoplasms / complications*
  • Brain Stem Neoplasms / pathology*
  • Brain Stem Neoplasms / physiopathology
  • Child, Preschool
  • Fatal Outcome
  • Female
  • Glioblastoma / complications*
  • Glioblastoma / physiopathology
  • Glioblastoma / secondary*
  • Humans
  • Hydrocephalus / etiology*
  • Hydrocephalus / pathology
  • Hydrocephalus / physiopathology
  • Magnetic Resonance Imaging
  • Meningeal Neoplasms / secondary*
  • Pia Mater / pathology
  • Spinal Cord / pathology
  • Subarachnoid Space / pathology
  • Subarachnoid Space / physiopathology