Neurogenic aspects of inflammation

Rheum Dis Clin North Am. 2005 Feb;31(1):77-101, ix. doi: 10.1016/j.rdc.2004.09.004.


The relationship between the inflammatory process and the nervous system is twofold. The nervous system is activated by inflammation which causes inflammatory pain and impaired motor function. Conversely, the nervous system acts back on the peripheral process. This is achieved by output systems at different levels, including primary afferent fibers (neurogenic inflammation), spinal cord (reflexes), and the brain (eg, neuroendocrine functions). This article first addresses the activation of the nociceptive system by inflammation; the second part describes the effects of the nervous system on inflamed tissue.

Publication types

  • Review

MeSH terms

  • Animals
  • Arthritis / etiology
  • Arthritis / metabolism
  • Arthritis / physiopathology*
  • Central Nervous System / physiopathology
  • Humans
  • Inflammation / etiology
  • Inflammation / metabolism
  • Inflammation / physiopathology*
  • Neurons, Afferent / physiology
  • Neuropeptides / physiology
  • Nociceptors / physiopathology*
  • Peptide Hydrolases / physiology


  • Neuropeptides
  • Peptide Hydrolases