Cannabidiol Prevents Infarction via the non-CB1 Cannabinoid Receptor Mechanism

Neuroreport. 2004 Oct 25;15(15):2381-5. doi: 10.1097/00001756-200410250-00016.

Abstract

Cannabidiol, a non-psychoactive constituent of cannabis, has been reported as a neuroprotectant. Cannabidiol and Delta(9)-tetrahydrocannabinol, the primary psychoactive constituent of cannabis, significantly decreased the infarct volume at 4 h in the mouse middle cerebral artery occlusion model. The neuroprotective effects of Delta(9)-tetrahydrocannabinol but not cannabidiol were inhibited by SR141716, a cannabinoid CB1 receptor antagonist, and were abolished by warming of the animals to the levels observed in the controls. Delta(9)-Tetrahydrocannabinol significantly decreased the rectal temperature, and the hypothermic effect was inhibited by SR141716. These results surely show that the neuroprotective effect of Delta(9)-tetrahydrocannabinol are via a CB1 receptor and temperature-dependent mechanisms whereas the neuroprotective effects of cannabidiol are independent of CB1 blockade and of hypothermia.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Body Temperature / drug effects
  • Brain Infarction / etiology
  • Brain Infarction / pathology
  • Brain Infarction / prevention & control*
  • Cannabidiol / therapeutic use*
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Dronabinol / therapeutic use
  • Drug Interactions
  • Fever / physiopathology
  • Infarction, Middle Cerebral Artery / complications
  • Infarction, Middle Cerebral Artery / drug therapy*
  • Male
  • Mice
  • Neuroprotective Agents / therapeutic use*
  • Piperidines / pharmacology
  • Pyrazoles / pharmacology
  • Receptor, Cannabinoid, CB1 / antagonists & inhibitors
  • Receptor, Cannabinoid, CB1 / physiology
  • Rimonabant
  • Tetrazolium Salts
  • Time Factors

Substances

  • Neuroprotective Agents
  • Piperidines
  • Pyrazoles
  • Receptor, Cannabinoid, CB1
  • Tetrazolium Salts
  • Cannabidiol
  • Dronabinol
  • triphenyltetrazolium
  • Rimonabant