Pyridine N-oxide derivatives: unusual anti-HIV compounds with multiple mechanisms of antiviral action

J Antimicrob Chemother. 2005 Feb;55(2):135-8. doi: 10.1093/jac/dkh530. Epub 2005 Jan 13.


Pyridine N-oxide derivatives represent a new class of anti-HIV compounds, for which some members exclusively act through inhibition of HIV-1 reverse transcriptase and thus characteristically behave as non-nucleoside reverse transcriptase inhibitors. Other members act, additionally or alternatively, at a post-integrational event in the replication cycle of HIV, that is, at the level of HIV gene expression. Repeated administration of one of the prototype compounds (JPL-32) to DBA/2 and hu-PBMC-SCID mice demonstrated, in the absence of any acute toxicity, protective activity against HIV-induced destruction of CD4 human T lymphocytes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-HIV Agents / chemistry*
  • Anti-HIV Agents / pharmacology*
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology
  • HIV-1 / drug effects
  • HIV-1 / physiology
  • HIV-2 / drug effects
  • HIV-2 / physiology
  • Humans
  • Pyridines / chemistry*
  • Pyridines / pharmacology*


  • Anti-HIV Agents
  • Antiviral Agents
  • Pyridines
  • pyridine N-oxide