DNA polymerase epsilon: in search of a function

Trends Biochem Sci. 1992 Feb;17(2):55-8. doi: 10.1016/0968-0004(92)90499-y.


The current model of eukaryotic DNA replication involves the two DNA polymerases delta and alpha as the leading and lagging strand enzymes, respectively. A DNA polymerase first discovered in yeast has now been found in all eukaryotic cells and is termed DNA polymerase epsilon. In yeast, the gene for DNA polymerase epsilon has recently been found to be essential for viability, raising new questions about its functions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA Polymerase III
  • DNA Repair / physiology
  • DNA Replication / physiology
  • DNA-Directed DNA Polymerase / genetics
  • DNA-Directed DNA Polymerase / physiology*
  • Eukaryotic Cells / physiology
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / physiology


  • DNA Polymerase III
  • DNA-Directed DNA Polymerase