[After your heart arrest, would you like to test a medicinal elixir?]

Rev Med Suisse. 2005 Feb 9;1(6):448-51.
[Article in French]


So far, cardiac arrest is still associated with high mortality or severe neurological disability in survivors. At the tissue level, cardiac arrest results into an acute condition of generalized hypoxia. A better understanding of the pathophysiology of ischemia-reperfusion and of the inflammatory response that develops after cardiac arrest could help to design novel therapeutic strategies in the future. It seems unlikely that a single drug, acting as a <<magic bullet>>, might be able to improve survival or neurological prognosis. Lessons learned from pathophysiological mechanisms rather indicate that combined therapies, involving thrombolysis, neuroprotective agents, antioxidants and anti-inflammatory molecules, together with temperature cooling, might represent helpful strategies to improve patient's outcome after cardiac arrest.

Publication types

  • English Abstract

MeSH terms

  • Anti-Inflammatory Agents / therapeutic use
  • Antioxidants / therapeutic use
  • Fibrinolytic Agents / therapeutic use
  • Heart Arrest / prevention & control*
  • Humans
  • Neuroprotective Agents / therapeutic use


  • Anti-Inflammatory Agents
  • Antioxidants
  • Fibrinolytic Agents
  • Neuroprotective Agents