Hypnotic activities of chamomile and passiflora extracts in sleep-disturbed rats

Biol Pharm Bull. 2005 May;28(5):808-10. doi: 10.1248/bpb.28.808.

Abstract

In the present study, we investigated hypnotic activities of chamomile and passiflora extracts using sleep-disturbed model rats. A significant decrease in sleep latency was observed with chamomile extract at a dose of 300 mg/kg, while passiflora extract showed no effects on sleep latency even at a dose of 3000 mg/kg. No significant effects were observed with both herbal extracts on total times of wakefulness, non-rapid eye movement (non-REM) sleep and REM sleep. Flumazenil, a benzodiazepine receptor antagonist, at a dose of 3 mg/kg showed a significant antagonistic effect on the shortening in sleep latency induced by chamomile extract. No significant effects were observed with chamomile and passiflora extracts on delta activity during non-REM sleep. In conclusion, chamomile extract is a herb having benzodiazepine-like hypnotic activity.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Chamomile*
  • Dose-Response Relationship, Drug
  • Electroencephalography / drug effects
  • Flowers
  • Hypnotics and Sedatives / isolation & purification
  • Hypnotics and Sedatives / pharmacology
  • Hypnotics and Sedatives / therapeutic use*
  • Male
  • Passiflora*
  • Plant Components, Aerial
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Rats
  • Rats, Wistar
  • Sleep Wake Disorders / drug therapy*
  • Sleep Wake Disorders / physiopathology

Substances

  • Hypnotics and Sedatives
  • Plant Extracts