Glycation, ageing and carnosine: are carnivorous diets beneficial?

Mech Ageing Dev. 2005 Oct;126(10):1034-9. doi: 10.1016/j.mad.2005.05.002.


Non-enzymic protein glycosylation (glycation) plays important roles in ageing and in diabetes and its secondary complications. Dietary constituents may play important roles in accelerating or suppressing glycation. It is suggested that carnivorous diets contain a potential anti-glycating agent, carnosine (beta-alanyl-histidine), whilst vegetarians may lack intake of the dipeptide. The possible beneficial effects of carnosine and related structures on protein carbonyl stress, AGE formation, secondary diabetic complications and age-related neuropathology are discussed.

Publication types

  • Review

MeSH terms

  • Aging / metabolism*
  • Aging / pathology
  • Animals
  • Carnosine / metabolism*
  • Diet, Vegetarian* / adverse effects
  • Glycosylation
  • Humans
  • Neurons / metabolism
  • Neurons / pathology


  • Carnosine