The Division of Violence Prevention at Centers for Disease Control and Prevention's (CDC) National Center for Injury Prevention and Control has had a long-standing interest in the prevention of child maltreatment. The nation's public health agency, CDC, seeks to focus the public health perspective on the problem of child maltreatment and to promote science-based practice in the field. Since 1999, CDC has developed research priorities to address the prevention of child maltreatment. Described here is a brief rationale for applying a public health approach to child maltreatment and a discussion of the priority-setting process, priorities in each of four areas of the public health model, and some of CDC's current child maltreatment prevention activities.