Evaluation of the Effect of Dietary Vegetable Consumption on Reducing Risk of Transitional Cell Carcinoma of the Urinary Bladder in Scottish Terriers

J Am Vet Med Assoc. 2005 Jul 1;227(1):94-100. doi: 10.2460/javma.2005.227.94.

Abstract

Objective: To evaluate the effects of vegetable consumption and vitamin supplementation on the risk of developing transitional cell carcinoma (TCC) of the urinary bladder in Scottish Terriers.

Design: Case-control study.

Animals: 92 adult Scottish Terriers with TCC (cases) and 83 Scottish Terriers with other conditions (controls).

Procedure: Owners of dogs with TCC completed a questionnaire regarding their dogs' diet and intake of vitamin supplements in the year prior to diagnosis of TCC; owners of control dogs completed the questionnaire for a comparable time period. The risk (odds ratio [OR]) of developing TCC associated with diet and vitamin supplementation was determined by use of logistic regression.

Results: After adjustment for age, weight, neuter status, and coat color, there was an inverse association between consumption of vegetables at least 3 times/wk (OR, 0.30; 95% confidence interval [CI], 0.15 to 0.62) and risk of developing TCC. For individual vegetable types, the risk of developing TCC was inversely associated with consumption of green leafy vegetables (OR, 0.12; 95% CI, 0.01 to 0.97) and yellow-orange vegetables (OR, 0.31; 95% CI, 0.14 to 0.70). Consumption of cruciferous vegetables was not significantly associated with a similar reduction in risk of developing TCC (OR, 0.22; CI, 0.04 to 1.11). The power of the study to detect a 50% reduction in TCC risk associated with daily vitamin supplementation was considered low (25%).

Conclusions and clinical relevance: Results suggest that consumption of certain vegetables may prevent or slow the development of TCC in Scottish Terriers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animal Feed*
  • Animal Nutritional Physiological Phenomena*
  • Animals
  • Carcinoma, Transitional Cell / epidemiology
  • Carcinoma, Transitional Cell / prevention & control
  • Carcinoma, Transitional Cell / veterinary*
  • Case-Control Studies
  • Confidence Intervals
  • Dog Diseases / diet therapy
  • Dog Diseases / epidemiology*
  • Dog Diseases / prevention & control
  • Dogs
  • Female
  • Logistic Models
  • Male
  • Multivariate Analysis
  • Odds Ratio
  • Risk Factors
  • Species Specificity
  • Surveys and Questionnaires
  • Urinary Bladder Neoplasms / epidemiology
  • Urinary Bladder Neoplasms / prevention & control
  • Urinary Bladder Neoplasms / veterinary*
  • Vegetables*
  • Vitamins / administration & dosage

Substances

  • Vitamins