Thyrotoxicosis and the heart

N Engl J Med. 1992 Jul 9;327(2):94-8. doi: 10.1056/NEJM199207093270206.


Many patients with thyrotoxicosis have clinical features that reflect the effects of excess thyroid hormone on the cardiovascular system. Thyrotoxicosis can aggravate preexisting cardiac disease and can also lead to atrial fibrillation, congestive heart failure, or worsening of angina pectoris. In elderly patients, these cardiac manifestations may dominate the clinical picture and warrant the measurement of the serum thyrotropin concentration. In the absence of preexisting cardiac disease, treatment of thyrotoxicosis usually results in a return of normal cardiac function.

Publication types

  • Review

MeSH terms

  • Heart / physiopathology
  • Heart Diseases / etiology*
  • Humans
  • Thyrotoxicosis / complications*
  • Thyrotoxicosis / physiopathology