Helicobacter pylori status in family members as risk factors for infection in children

Epidemiol Infect. 2005 Aug;133(4):645-52. doi: 10.1017/s0950268805003900.


This study aimed to disentangle the independent contributions of Helicobacter pylori infections in mothers, fathers and siblings to the risk for the infection in the 11-13 years age group. Index children from a cross-sectional Stockholm school survey and their family members completed questionnaires and contributed blood samples. H. pylori serostatus was determined with an enzyme-linked immunosorbent assay and immunoblot. Fifty-four seropositive and 108 seronegative index children were included and 480 out of 548 family members contributed blood. In multivariate logistic regression modelling, having an infected mother (OR 11.6, 95% CI 2.0-67.9) or at least one infected sibling (OR 8.1, 95% CI 1.8-37.3) were risk factors for index child infection, whilst the influence of infected fathers was non-significant. Birth in high-prevalence countries was an independent risk factor (OR 10.4, 95% CI 3.4-31.3). H. pylori infections in mothers and siblings and birth in high-prevalence countries stand out as strong markers of infection risk amongst children in Sweden.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Distribution
  • Child
  • Confidence Intervals
  • Cross-Sectional Studies
  • Disease Transmission, Infectious / statistics & numerical data*
  • Family
  • Female
  • Follow-Up Studies
  • Helicobacter Infections / blood
  • Helicobacter Infections / epidemiology*
  • Helicobacter Infections / transmission*
  • Helicobacter pylori / isolation & purification*
  • Humans
  • Incidence
  • Logistic Models
  • Male
  • Middle Aged
  • Odds Ratio
  • Risk Factors
  • Sex Distribution
  • Sweden / epidemiology