Peyer patches are not required for acute graft-versus-host disease after myeloablative conditioning and murine allogeneic bone marrow transplantation

Blood. 2006 Jan 1;107(1):410-2. doi: 10.1182/blood-2004-11-4565. Epub 2005 Sep 13.


Graft-versus-host disease (GVHD) is a multistep disease process following allogeneic bone marrow transplantation (BMT). It has been postulated that the induction of acute GVHD requires the presence of Peyer patches (PPs). A new tumor necrosis factor (TNF)-deficient strain has been developed that totally lacks PPs and displays the defects characteristic of TNF ablation but not lymphotoxin-associated defects characterized by lack of both PPs and lymph nodes. To determine the necessity of PPs in acute lethal GVHD induction, we transplanted full major histocompatibility complex (MHC)-mismatched grafts into myeloablated TNF knockout recipients. No differences in the survival or GVHD-associated histopathologic lesions were observed between the recipients. We conclude that neither PPs nor host TNF-alpha is required for the development of acute lethal GVHD in mice that undergo myeloablative conditioning and allogeneic BMT.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Animals
  • Bone Marrow Transplantation / adverse effects*
  • Graft vs Host Disease / etiology*
  • Graft vs Host Disease / pathology
  • Intestinal Diseases / etiology
  • Mice
  • Mice, Knockout
  • Peyer's Patches / physiology*
  • Transplantation Conditioning / methods
  • Transplantation, Homologous
  • Tumor Necrosis Factor-alpha / deficiency


  • Tumor Necrosis Factor-alpha