Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum

Trends Genet. 2005 Dec;21(12):664-72. doi: 10.1016/j.tig.2005.09.005. Epub 2005 Oct 10.


In contrast to the common and genetically complex senile form of Alzheimer's disease (AD), the molecular genetic dissection of inherited presenile dementias has given important mechanistic insights into the pathogenesis of degenerative brain disease. Here, we focus on recent genotype-phenotype correlative studies in presenile AD and the frontotemporal dementia (FTD) complex of disorders. Together, these studies suggest that AD and FTD are linked in a genetic spectrum of presenile degenerative brain disorders in which tau appears to be the central player.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / genetics*
  • Alzheimer Disease / metabolism
  • Alzheimer Disease / physiopathology
  • Alzheimer Disease / psychology
  • Amyloid beta-Protein Precursor / genetics*
  • Amyloid beta-Protein Precursor / physiology
  • Humans
  • Membrane Proteins / genetics*
  • Membrane Proteins / physiology
  • Nerve Tissue Proteins / genetics*
  • Nerve Tissue Proteins / physiology
  • Phenotype
  • Presenilin-1
  • tau Proteins


  • Amyloid beta-Protein Precursor
  • MAPT protein, human
  • Membrane Proteins
  • Nerve Tissue Proteins
  • PSEN1 protein, human
  • Presenilin-1
  • tau Proteins