Topiramate treatment in bulimia nervosa patients: a randomized, double-blind, placebo-controlled trial

Int J Eat Disord. 2005 Dec;38(4):295-300. doi: 10.1002/eat.20202.


Objective: The aim of the current study was to test the influence of topiramate on behavior, body weight, and health-related quality of life (HRQOL) in bulimic patients.

Method: Thirty patients with bulimia nervosa were treated with topiramate in a 10-week randomized, double-blind, placebo-controlled study. The subjects were randomly assigned to receive topiramate (topiramate group [TG]; n = 30) or a placebo (control group [CG]; n = 30). Primary outcome measures were changes in the frequency of binging/purging, in body weight, and on the SF-36 Health Survey (SF-36) scales.

Results: In comparison to the CG group (according to the intent-to-treat principle), significant changes in the frequency of binging/purging (a > 50% reduction: TG, n = 11 [36.7%]; CG, n = 1 [3.3%]; p < .001), body weight (difference in weight loss between the two groups: 3.8 kg, 95% confidence interval [CI] = -5.4 to -2.1; p < .001), and SF-36 (all ps < .001) could be seen. All patients tolerated topiramate well.

Conclusion: Topiramate appears to safe and effective in influencing the frequency of binging/purging, body weight, and HRQOL in bulimic patients.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Anticonvulsants / therapeutic use*
  • Attitude to Health
  • Bulimia / drug therapy*
  • Comorbidity
  • Double-Blind Method
  • Female
  • Fructose / analogs & derivatives*
  • Fructose / therapeutic use
  • Health Behavior
  • Humans
  • Personality Assessment / statistics & numerical data
  • Psychometrics
  • Topiramate
  • Treatment Outcome


  • Anticonvulsants
  • Topiramate
  • Fructose