The contributions of biosynthesis and acyl chain remodelling to the molecular species profile of phosphatidylcholine in yeast

Biochem Soc Trans. 2005 Nov;33(Pt 5):1146-9. doi: 10.1042/BST20051146.


Phosphatidylcholine (PC) is a very abundant membrane lipid in most eukaryotes, including yeast. The molecular species profile of PC, i.e. the ensemble of PC molecules with acyl chains differing in number of carbon atoms and double bonds, is important for membrane function. Pathways of PC synthesis and turnover maintain PC homoeostasis and determine the molecular species profile of PC. Studies addressing the processes involved in establishing the molecular species composition of PC in yeast using stable isotope labelling combined with detection by MS are reviewed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Phosphatidylcholines / biosynthesis
  • Phosphatidylcholines / chemistry
  • Phosphatidylcholines / metabolism*
  • Saccharomyces cerevisiae / metabolism*
  • Species Specificity
  • Structure-Activity Relationship


  • Phosphatidylcholines