Therapeutic effects of bacteriophage Cpl-1 lysin against Streptococcus pneumoniae endocarditis in rats

J M Entenza; J M Loeffler; D Grandgirard; V A Fischetti; P Moreillon

doi:10.1128/AAC.49.11.4789-4792.2005

Therapeutic effects of bacteriophage Cpl-1 lysin against Streptococcus pneumoniae endocarditis in rats

Antimicrob Agents Chemother. 2005 Nov;49(11):4789-92. doi: 10.1128/AAC.49.11.4789-4792.2005.

Authors

J M Entenza¹, J M Loeffler, D Grandgirard, V A Fischetti, P Moreillon

Affiliation

¹ Department of Fundamental Microbiology, Biology Building, University of Lausanne, CH-1015 Lausanne, Switzerland. Jose.Entenza@unil.ch

Abstract

Cpl-1, a pneumococcal phage lytic enzyme, was tested in rats with experimental endocarditis due to Streptococcus pneumoniae WB4. High-dose regimen Cpl-1 eliminated pneumococci from blood within 30 min and decreased bacterial titers in vegetations (>4 log10 CFU/g) within 2 h. Rapid bacterial lysis induced by Cpl-1 treatment increased cytokine secretion noticeably.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Cytokines / biosynthesis
Endocarditis, Bacterial / drug therapy*
Endocarditis, Bacterial / microbiology
Enzyme Therapy*
Enzymes
Pneumococcal Infections / drug therapy*
Pneumococcal Infections / microbiology
Rats

Substances

Cytokines
Enzymes
lysin, streptococcus bacteriophage