Neuroenergetics and the kinetic design of excitatory synapses

Nat Rev Neurosci. 2005 Nov;6(11):841-9. doi: 10.1038/nrn1784.


Why is the characteristic timescale of neural information processing in the millisecond range, corresponding to a 'clock speed' of about 1 kHz, whereas the clock speed of modern computers is about 3 GHz? Here we investigate how the brain's energy supply limits the maximum rate at which the brain can compute, and how the molecular components of excitatory synapses have evolved properties that are matched to the information processing they perform.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / metabolism
  • Brain / physiology*
  • Energy Metabolism / physiology*
  • Humans
  • Kinetics
  • Mental Processes / physiology*
  • Synapses / physiology*