Venous ulcers: microcirculatory improvement and faster healing with local use of Pycnogenol

Angiology. 2005 Nov-Dec;56(6):699-705. doi: 10.1177/000331970505600607.


Chronic venous insufficiency (CVI) causes a well-defined microangiopathy described as venous hypertensive microangiopathy (VHM) leading to venous ulcerations. VHM is mainly observed in the distal part of the leg, in the perimalleolar region. In VHM edema is the consequence of increased capillary pressure and reduced local clearance, and this affects local perfusion. The healing of venous ulcers is usually very slow. Many treatments are available, but there is still no standard. Oral Pycnogenol is effective in venous disease and particularly in controlling edema. The aim of this study was the evaluation of the local effects of Pycnogenol on ulcers healing associated with venous hypertension. The study lasted 6 weeks including 18 patients (16 completed the study) with venous ulcerations. The oral treatment with Pycnogenol was compared with a combination treatment including oral and local treatment. In subjects treated with the combination treatment (oral and local), venous ulcers healed better (there was a faster reduction in ulcerated area) in comparison with oral treatment only. According to this pilot study Pycnogenol appears to have an important role in local treatment of venous ulcers improving healing and signs/symptoms.

Publication types

  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Administration, Cutaneous
  • Administration, Oral
  • Female
  • Flavonoids / administration & dosage*
  • Humans
  • Male
  • Microcirculation / physiopathology
  • Middle Aged
  • Plant Extracts
  • Platelet Aggregation Inhibitors / administration & dosage*
  • Time Factors
  • Varicose Ulcer / drug therapy*
  • Varicose Ulcer / physiopathology*
  • Wound Healing / physiology


  • Flavonoids
  • Plant Extracts
  • Platelet Aggregation Inhibitors
  • pycnogenols