Myasthenic crisis

Neurocrit Care. 2005;3(3):189-94. doi: 10.1385/NCC:3:3:189.


Myasthenic crisis is a serious occurrence, affecting up to 27% of patients with myasthenia gravis. In the approach to the patient with myasthenic crisis, (1) the diagnosis of myasthenia gravis is confirmed; (2) respiratory failure is evaluated and treated in the intensive care unit, while potential precipitating factors are identified and managed; (3) immunomodulatory treatment is initiated; and (4) complications are avoided or managed promptly. The mortality rate should be 5% or less, with the elderly being most vulnerable.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Critical Illness
  • Diagnosis, Differential
  • Humans
  • Intensive Care Units
  • Myasthenia Gravis / complications*
  • Prognosis
  • Respiratory Insufficiency / etiology*