Association between the dopamine D2 receptor TaqI A2 allele and low activity COMT allele with obsessive-compulsive disorder in males

Eur Neuropsychopharmacol. 2006 Aug;16(6):446-50. doi: 10.1016/j.euroneuro.2005.12.001. Epub 2006 Jan 19.


Background: Mounting evidence suggests the involvement of the dopamine system in the pathophysiology of obsessive-compulsive disorder.

Method: The relationship of the dopamine D(2) receptor (DRD2) TaqI A, and catechol-O-methyl-transferase (COMT) NlaIII High/Low activity polymorphism to obsessive-compulsive disorder (OCD) was examined in a sample of 150 patients and 150 controls.

Results: OCD patients did not show significant differences in genotype distribution and allele frequency for polymorphisms investigated relative to controls. However, when the sample was stratified by gender, there was a trend to a significant predominance of the DRD2 A2A2 genotype (p=0.049), and a higher frequency of the DRD2 A2 allele (p=0.020) and low-activity COMT allele (p=0.035) in male OCD patients compared to male controls. In addition, we observed an association of the DRD2 A2A2 genotype in patients with an early onset of disease (<or=15 years) (p=0.033).

Conclusions: Our findings replicate previous reports and provide support for a potential role of the COMT and DRD2 locus in subgroup of male, early onset patients with OCD.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Alleles*
  • Catechol O-Methyltransferase / genetics*
  • Catechol O-Methyltransferase / metabolism
  • Deoxyribonucleases, Type II Site-Specific / genetics
  • Female
  • Gene Frequency / genetics
  • Genetic Linkage / genetics
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Obsessive-Compulsive Disorder / genetics*
  • Obsessive-Compulsive Disorder / metabolism
  • Receptors, Dopamine D2 / genetics*
  • Receptors, Dopamine D2 / metabolism
  • Sex Characteristics*


  • Receptors, Dopamine D2
  • Catechol O-Methyltransferase
  • Deoxyribonucleases, Type II Site-Specific
  • TCGA-specific type II deoxyribonucleases