Salmonella enterica strains lacking the frataxin homolog CyaY show defects in Fe-S cluster metabolism in vivo

J Bacteriol. 2006 Feb;188(3):1175-9. doi: 10.1128/JB.188.3.1175-1179.2006.


In Salmonella enterica, the isc operon contains genes necessary for the synthesis of Fe-S clusters and strains lacking this operon have severe defects in a variety of cellular processes. Other cellular loci that impact Fe-S cluster synthesis to a lesser extent have been described. The cyaY locus encodes a frataxin homolog, and it is shown here that lesions in this locus affect Fe-S cluster metabolism. When present in combination with other lesions, mutations in cyaY can result in a strain with more severe defects than those lacking the isc locus.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Bacterial Proteins / chemistry
  • Bacterial Proteins / metabolism*
  • Escherichia coli Proteins
  • Frataxin
  • Iron-Binding Proteins / chemistry*
  • Iron-Binding Proteins / genetics
  • Iron-Binding Proteins / metabolism
  • Iron-Sulfur Proteins / genetics
  • Iron-Sulfur Proteins / metabolism*
  • Salmonella enterica / genetics
  • Salmonella enterica / growth & development
  • Salmonella enterica / metabolism*


  • Bacterial Proteins
  • CyaY protein, E coli
  • Escherichia coli Proteins
  • Iron-Binding Proteins
  • Iron-Sulfur Proteins