Folinic acid-responsive seizures initially responsive to pyridoxine

Pediatr Neurol. 2006 Feb;34(2):164-7. doi: 10.1016/j.pediatrneurol.2005.08.019.


This report presents a male who developed clonic seizures on the day he was born. The next day, the diagnosis of pyridoxine-dependent seizures was made. However, contradictory to this diagnosis, seizures reappeared despite treatment with pyridoxine. Seizures ceased after folinic acid was initiated. The clinical and biochemical characteristics of folinic acid-responsive seizures are reviewed. Treatment with folinic acid should be considered in neonatal seizures of unknown origin that do not respond to pyridoxine, or manifest a transient response to pyridoxine.

Publication types

  • Case Reports

MeSH terms

  • Epilepsy / cerebrospinal fluid
  • Epilepsy / drug therapy*
  • Epilepsy / etiology
  • Humans
  • Infant
  • Infant, Newborn
  • Leucovorin / cerebrospinal fluid
  • Leucovorin / therapeutic use*
  • Male
  • Metabolism, Inborn Errors / complications
  • Pyridoxine / therapeutic use*
  • Treatment Outcome
  • Vitamin B Complex / therapeutic use*


  • Vitamin B Complex
  • Pyridoxine
  • Leucovorin