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. 1991 Sep;196(1):33-9.
doi: 10.1016/0014-4827(91)90453-2.

A Role for Both RB and p53 in the Regulation of Human Cellular Senescence

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A Role for Both RB and p53 in the Regulation of Human Cellular Senescence

J W Shay et al. Exp Cell Res. .

Abstract

We present evidence for the possible involvement of both the RB and p53 proteins in the regulation of cellular senescence. Human fibroblasts immortalized with an inducible SV40 T-antigen become senescent following the de-induction of T-antigen. Plasmids expressing an alternative source of intact T-antigen restore proliferation but T-antigen deletion mutants lacking either the RB or p53 binding domains are unable to do so. Similarly, combinations of adenovirus E1A + E1B or human papillomavirus E6 + E7 genes are able to replace T-antigen functions and permit cell proliferation, whereas the individual genes do not. These results are discussed in terms of a two-stage model for the escape from in vitro cellular senescence.

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