The expanding cosmos of nuclear receptor coactivators

David M Lonard; Bert W O'Malley

doi:10.1016/j.cell.2006.04.021

The expanding cosmos of nuclear receptor coactivators

Cell. 2006 May 5;125(3):411-4. doi: 10.1016/j.cell.2006.04.021.

Authors

David M Lonard¹, Bert W O'Malley

Affiliation

¹ Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

PMID: 16678083
DOI: 10.1016/j.cell.2006.04.021

Abstract

About 200 coactivators play a central role in promoting gene expression mediated by nuclear receptors. This diverse group of proteins are key integrators of signals from steroid hormones and have been implicated in cancer and other diseases.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Active Transport, Cell Nucleus / physiology
Animals
Cell Nucleus / genetics
Cell Nucleus / metabolism*
Gene Expression Regulation / physiology
Histones / metabolism
Humans
Receptors, Cytoplasmic and Nuclear / genetics
Receptors, Cytoplasmic and Nuclear / metabolism*
Regulatory Elements, Transcriptional / physiology
Trans-Activators / physiology*
Transcription Factors / physiology*
Transcriptional Activation / physiology*

Substances

Histones
Receptors, Cytoplasmic and Nuclear
Trans-Activators
Transcription Factors

Abstract

Publication types

MeSH terms

Substances

Grants and funding