Spontaneous splenic rupture in a healthy allogeneic donor of peripheral-blood stem cell following the administration of granulocyte colony-stimulating factor (g-csf). A case report and review of the literature

Haematologica. 2006 May;91(5 Suppl):ECR08.


Human granulocyte colony-stimulating factor (G-CSF) is a hematopoietic hormone promoting the growth, proliferation, differentiation and maturation of myeloid and leukocytic lineages. G-csfs have been used to improve granulocyte count in neutropenic patients, reduce the incidence and duration of neutropenia in patients receiving cytotoxic chemotherapy and to mobilize peripheral blood stem cells prior to leukapheresis for using in both autologous and allogeneic hematopoietic cell transplantation. In general, side-effects are mild to moderate and life threatening side-effects like splenic rupture are very rare. We herein, report a case of spontaneous splenic rupture secondary to high-dose G-CSF use (20 mcg/kg/day), in a healthy female allogeneic donor of peripheral-blood stem cell (PBSC) .

Publication types

  • Case Reports
  • Review

MeSH terms

  • Abdominal Pain / etiology
  • Adult
  • Female
  • Filgrastim
  • Granulocyte Colony-Stimulating Factor / adverse effects*
  • Hematopoietic Stem Cell Mobilization / adverse effects*
  • Hemoperitoneum / etiology
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / surgery
  • Living Donors*
  • Male
  • Peripheral Blood Stem Cell Transplantation*
  • Recombinant Proteins
  • Rupture, Spontaneous
  • Splenectomy
  • Splenic Rupture / diagnosis
  • Splenic Rupture / etiology*
  • Splenic Rupture / surgery
  • Splenomegaly / chemically induced


  • Recombinant Proteins
  • Granulocyte Colony-Stimulating Factor
  • Filgrastim