A comprehensive pathway map of epidermal growth factor receptor signaling

Mol Syst Biol. 2005:1:2005.0010. doi: 10.1038/msb4100014. Epub 2005 May 25.


The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells. Reflecting this importance, it is one of the best-investigated signaling systems, both experimentally and computationally, and several computational models have been developed for dynamic analysis. A map of molecular interactions of the EGFR signaling system is a valuable resource for research in this area. In this paper, we present a comprehensive pathway map of EGFR signaling and other related pathways. The map reveals that the overall architecture of the pathway is a bow-tie (or hourglass) structure with several feedback loops. The map is created using CellDesigner software that enables us to graphically represent interactions using a well-defined and consistent graphical notation, and to store it in Systems Biology Markup Language (SBML).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Endocytosis
  • Enzyme Activation
  • ErbB Receptors / physiology*
  • Feedback, Physiological
  • Humans
  • Models, Biological*
  • Multigene Family
  • Programming Languages
  • Protein Interaction Mapping
  • Receptors, G-Protein-Coupled / physiology
  • Signal Transduction*
  • Software


  • Receptors, G-Protein-Coupled
  • ErbB Receptors