[Evaluation of the effect of fertility-saving surgery on young patients with malignant ovarian tumors]

Zhonghua Fu Chan Ke Za Zhi. 2006 Apr;41(4):233-6.
[Article in Chinese]

Abstract

Objective: To evaluate the impact of fertility-saving surgery and adjuvant chemotherapy on survival and fertility of young patients with ovarian malignant tumors.

Methods: A retrospective analysis was done on 38 patients with ovarian malignant germ cell tumors, 22 patients with malignant epithelial tumors and 4 patients with sexual cord mesenchymal tumors receiving conservative treatments. Outcomes such as menstruation and reproduction ability were assessed.

Results: Fifty-nine among 64 patients have been alive up to now (92%). The overall survival rate for ovarian epithelial malignancies, malignant germ cell tumors and sexual cord mesenchymal tumors were 95% (21/22), 89% (34/38) and 4/4, respectively. Fifteen patients received second operation and recurrence was found in 6 patients. Among the 59 surviving patients, 53 had normal menstruation. Thirteen patients among 20 patients who wanted to get pregnant had 15 pregnancies and 9 successful deliveries.

Conclusions: The management of fertility-saving surgery on patients with ovarian malignant germ cell tumors, whatever the stagings are, is a safe option. For patients with ovarian epithelial carcinomas, fertility-saving surgery is only indicated for low-stage (stage I), high-grade (G1), and patients who hope to maintain fertility function eagerly. Cisplatinum-based combination chemotherapy is necessary. Standardized chemotherapy has no effect on fertility function.

Publication types

  • Evaluation Study

MeSH terms

  • Adolescent
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Chemotherapy, Adjuvant
  • Child
  • Female
  • Fertility*
  • Follow-Up Studies
  • Germinoma / drug therapy
  • Germinoma / mortality
  • Germinoma / surgery*
  • Humans
  • Lymph Node Excision
  • Neoplasm Recurrence, Local
  • Neoplasm Staging
  • Ovarian Neoplasms / drug therapy
  • Ovarian Neoplasms / mortality
  • Ovarian Neoplasms / surgery*
  • Ovariectomy / methods*
  • Pregnancy
  • Pregnancy Outcome
  • Reproducibility of Results
  • Retrospective Studies
  • Survival Rate
  • Treatment Outcome