Drug-induced nail diseases

Dermatol Clin. 2006 Jul;24(3):387-91. doi: 10.1016/j.det.2006.03.004.


Although many nail disorders have been associated with drug intake, most reports are anecdotal. Most nail changes caused by drugs are the outcome of acute toxicity to the nail epithelia; nail symptoms depend on which nail structure is damaged. The most com-mon symptoms include Beau's lines/onychomadesis, melanonychia, onycholysis, and periungual pyogenic granulomas. Drug-induced nail abnormalities are usually transitory and disappear with drug withdrawal, but sometimes persist over time. This article reviews drugs that have been consistently associated with nail abnormalities.

Publication types

  • Review

MeSH terms

  • Adrenergic beta-Antagonists / adverse effects
  • Anti-Retroviral Agents / adverse effects
  • Anticoagulants / adverse effects
  • Anticonvulsants / adverse effects
  • Antimalarials / adverse effects
  • Antineoplastic Agents / adverse effects
  • Humans
  • Metals, Heavy / adverse effects
  • Nail Diseases / chemically induced*
  • Nail Diseases / diagnosis*
  • Nail Diseases / pathology
  • Retinoids / adverse effects


  • Adrenergic beta-Antagonists
  • Anti-Retroviral Agents
  • Anticoagulants
  • Anticonvulsants
  • Antimalarials
  • Antineoplastic Agents
  • Metals, Heavy
  • Retinoids