The effect of a daily facial cleanser for normal to oily skin on the skin barrier of subjects with acne

Cutis. 2006 Jul;78(1 Suppl):34-40.


Acne vulgaris is a common skin disorder that affects many people every year, especially the teenaged population. People with acne find the condition especially difficult to manage because of the disease's chronicity and variability in response to treatment. Acne is the result of pores clogged with shed skin cells combined with sebum in the hair follicle. Successful treatment of acne is important because acne has the potential to result in lasting physical and emotional scarring. For many years, physicians have agreed that although cleansing is not effective on its own, effective cleansing is an important part of any acne treatment regimen. However, patients have not been satisfied with the types of cleansers available. In addition to containing dyes and perfumes that can irritate and exacerbate acne, these cleansers often are too harsh and can result in excessive drying of the skin, which leads to overcompensation by the oil glands and ultimately to more oil on the surface of the skin. This study examined the use of a daily facial cleanser formulated for normal to oily skin in subjects with mild facial acne. The cleanser was studied for 2 weeks in the absence of additional treatments to eliminate the confounding effects of various treatments. Subjects were monitored for skin barrier function through transepidermal water loss (TEWL) and corneometry, sebum level, and lesion counts. The results of the study indicate that the facial cleanser is gentle and does not damage the skin barrier or result in sebum overcompensation; additionally, the cleanser is effective at deep-pore cleansing, which may help to manage some acne-associated symptoms.

MeSH terms

  • Acne Vulgaris / prevention & control*
  • Administration, Topical
  • Adolescent
  • Adult
  • Child
  • Dermatologic Agents / administration & dosage
  • Dermatologic Agents / therapeutic use*
  • Face
  • Female
  • Humans
  • Male
  • Middle Aged
  • Patient Compliance
  • Sebum / drug effects
  • Severity of Illness Index
  • Skin Care / methods*
  • Treatment Outcome
  • Water Loss, Insensible


  • Dermatologic Agents