Subcutaneous extralesional triamcinolone acetonide injection versus conservative management in the treatment of chalazion

Hong Kong Med J. 2006 Aug;12(4):278-81.


Objective: To compare the efficacy of subcutaneous extralesional triamcinolone acetonide injection versus conservative treatment for chalazion.

Design: Randomised controlled trial.

Setting: Eye clinics of two regional hospitals in Hong Kong.

Patients: Patients over 18 years old presenting with primary chalazion were randomised into two groups. In group 1, 12 patients were treated with lid hygiene, warm compresses, and chloramphenicol 1% ointment 4 times a day. In group 2, 16 patients were treated with 0.3 mL triamcinolone acetonide (10 mg/mL) injection to the subcutaneous tissue extralesionally via the percutaneous route. Exclusion criteria were: acutely infected chalazion with preseptal cellulitis, recurrent chalazion, small chalazion (< or =2 mm), and prior treatment to chalazion.

Main outcome measures: Size of chalazion, recurrence of chalazion, intra-ocular pressure, and complications from treatment, including skin pigmentary change or atrophy and pyogenic granuloma.

Results: There was a clinically and statistically significant difference between the success rates in group 1 (58.3%) and group 2 (93.8%). In group 1, the mean prior duration of chalazion before treatment was significantly shorter in success cases than in failed cases. One patient with multiple chalazia in group 2 developed hypopigmentary skin changes at one treatment site.

Conclusion: Subcutaneous extralesional triamcinolone acetonide injection was more effective than conservative treatment for chalazion.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Chalazion / drug therapy*
  • Female
  • Humans
  • Injections, Subcutaneous
  • Male
  • Middle Aged
  • Triamcinolone Acetonide / administration & dosage*


  • Triamcinolone Acetonide