MMM: a sequence-to-structure alignment protocol

Bioinformatics. 2006 Nov 1;22(21):2691-2. doi: 10.1093/bioinformatics/btl449. Epub 2006 Aug 23.


Motivation: Accurate alignment of a target sequence to a template structure continues to be a bottleneck in producing good quality comparative protein structure models.

Results: Multiple Mapping Method (MMM) is a comparative protein structure modeling server with an emphasis on a novel alignment optimization protocol. MMM takes inputs from five profile-to-profile based alignment methods. The alternatively aligned regions from the input alignment set are combined according to their fit in the structural environment of the template structure. The resulting, optimally spliced MMM alignment is used as input to an automated comparative modeling module to produce a full atom model.

Availability: The MMM server is freely accessible at

Publication types

  • Evaluation Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Amino Acid Sequence
  • Computer Simulation
  • Internet
  • Models, Molecular*
  • Molecular Sequence Data
  • Protein Structure, Secondary
  • Sequence Analysis, Protein / methods*
  • Software*