The Use of a Cissus Quadrangularis Formulation in the Management of Weight Loss and Metabolic Syndrome

Lipids Health Dis. 2006 Sep 2;5:24. doi: 10.1186/1476-511X-5-24.

Abstract

Aim: Once considered a problem of developed countries, obesity and obesity-related complications (such as metabolic syndrome) are rapidly spreading around the globe. The purpose of the present study was to investigate the use of a Cissus quadrangularis formulation in the management of metabolic syndrome, particularly weight loss and central obesity.

Methods: The study was a randomized, double-blind, placebo-controlled design involving 123 overweight and obese persons (47.2% male; 52.8% female; ages 19-50). The 92 obese (BMI >30) participants were randomized into three groups; placebo, formulation/no diet, and formulation/diet (2100-2200 calories/day). The 31 overweight participants (BMI = 25-29) formed a fourth (no diet) treatment group. All participants received two daily doses of the formulation or placebo and remained on a normal or calorie-controlled diet for 8 weeks.

Results: At the end of the trial period, statistically significant net reductions in weight and central obesity, as well as in fasting blood glucose, total cholesterol, LDL-cholesterol, triglycerides, and C-reactive protein were observed in participants who received the formulation, regardless of diet.

Conclusion: Cissus quadrangularis formulation appears to be useful in the management of weight loss and metabolic syndrome.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Anti-Obesity Agents / administration & dosage
  • Anti-Obesity Agents / therapeutic use
  • Blood Glucose / metabolism
  • Body Mass Index
  • Body Weight / drug effects
  • Cholesterol / blood
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Cissus / chemistry*
  • Diarrhea / chemically induced
  • Diet, Reducing*
  • Double-Blind Method
  • Female
  • Headache / chemically induced
  • Humans
  • Male
  • Metabolic Syndrome / blood
  • Metabolic Syndrome / diet therapy*
  • Middle Aged
  • Obesity / blood
  • Obesity / diet therapy
  • Overweight / drug effects
  • Plant Extracts / administration & dosage
  • Plant Extracts / adverse effects
  • Plant Extracts / therapeutic use*
  • Prospective Studies
  • Treatment Outcome
  • Triglycerides / blood
  • Weight Loss / drug effects*

Substances

  • Anti-Obesity Agents
  • Blood Glucose
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Plant Extracts
  • Triglycerides
  • Cholesterol