Manganese superoxide dismutase: nucleotide and deduced amino acid sequence of a cDNA encoding a new human transcript

Biochim Biophys Acta. 1990 Oct 23;1087(2):250-2. doi: 10.1016/0167-4781(90)90213-l.


Three human cDNA libraries were screened with a human manganese superoxide dismutase (Mn-SOD) cDNA under moderately stringent conditions to characterize a large 4-6 kb RNA species which hybridizes to Mn-SOD in RNA blot analyses. A new 4.2 kb Mn-SOD cDNA clone (Mn-SOD 1) was isolated. Its long 3426 nucleotide 3'-untranslated sequence contains both of the 240 base 3'-untranslated sequences of the 1 kb Mn-SOD 4 and 5 cDNAs. This is a fully processed, cytoplasmic RNA species and raises the possibility of a role for particular 3'-untranslated sequence selection in Mn-SOD gene regulation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • DNA / genetics
  • Humans
  • Molecular Sequence Data
  • RNA / genetics
  • Superoxide Dismutase / genetics*
  • Transcription, Genetic*


  • RNA
  • DNA
  • Superoxide Dismutase

Associated data

  • GENBANK/M34665