Myxofibrosarcoma of the neck

J Laryngol Otol. 2006 Oct;120(10):872-4. doi: 10.1017/S0022215106001113.


We report a rare case of myxofibrosarcoma arising in the neck. A 55-year-old man presented with a two-year history of left-sided, painless, submandibular swelling. Computed tomography and magnetic resonance imaging (MRI) revealed an 80 x 35 mm, well defined, lobulated, submandibular tumour extending to the parapharyngeal space. The tumour showed uniformly low intensity and marked hyperintensity in T1- and T2-weighted MRI scans, respectively, and was scarcely enhanced by gadolinium. A tentative diagnosis of lymphangioma or plunging ranula was made, and the patient underwent local injection of OK-432, which proved to be ineffective. Resection of the tumour was then performed via a transcervical approach. The tumour was histopathologically and immunohistochemically diagnosed as a low-grade myxofibrosarcoma. The patient's post-operative clinical course was uneventful, and the patient was free of disease 27 months after surgery. The pathology, clinical characteristics and treatment of myxofibrosarcoma are bibliographically reviewed.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antineoplastic Agents / therapeutic use
  • Head and Neck Neoplasms / diagnosis*
  • Head and Neck Neoplasms / drug therapy
  • Head and Neck Neoplasms / surgery
  • Histiocytoma, Malignant Fibrous / diagnosis*
  • Histiocytoma, Malignant Fibrous / drug therapy
  • Histiocytoma, Malignant Fibrous / surgery
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Picibanil / therapeutic use
  • Tomography, X-Ray Computed


  • Antineoplastic Agents
  • Picibanil