The effects of chewing versus caffeine on alertness, cognitive performance and cardiac autonomic activity during sleep deprivation

J Sleep Res. 2006 Dec;15(4):358-68. doi: 10.1111/j.1365-2869.2006.00547.x.


Chewing has been shown to alleviate feelings of sleepiness and improve cognitive performance during the day. This study investigated the effect of chewing on alertness and cognitive performance across one night without sleep as well as the possible mediating role of cardiac autonomic activity. Fourteen adults participated in a randomized, counterbalanced protocol employing a chewing, placebo and caffeine condition. Participants completed tasks assessing psychomotor vigilance, tracking, grammatical reasoning, alertness and sleepiness each hour across the night. All participants received either placebo or caffeine (200 mg), while the chewing condition also chewed on a tasteless and odorless substance for 15 min each hour. Heart rate (HR), root mean square of the successive differences in R-R intervals on the ECG (RMSSD), and preejection period (PEP) were simultaneously recorded. Alertness and cognitive performance amongst the chewing condition did not differ or were in fact worse when compared with placebo. Similarly, measures of HR and RMSSD remained the same between these two conditions; however, PEP was reduced in the later part of the night in the chewing condition compared with a relative increase for placebo. Caffeine led to improved speed and accuracy on cognitive tasks and increased alertness when compared with chewing. Relative increases in RMSSD and reductions in HR were demonstrated following caffeine; however, no change in PEP was seen. Strong associations between cardiac parasympathetic activity and complex cognitive tasks, as well as between subjective alertness and simpler cognitive tasks, suggest a differential process mediating complex versus simple cognitive performance during sleep deprivation.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Arousal / drug effects*
  • Arousal / physiology*
  • Attention / drug effects*
  • Attention / physiology*
  • Autonomic Nervous System / drug effects*
  • Autonomic Nervous System / physiopathology*
  • Caffeine / pharmacology*
  • Chewing Gum
  • Electrocardiography / drug effects
  • Female
  • Heart Rate / drug effects*
  • Heart Rate / physiology*
  • Humans
  • Male
  • Mastication / physiology*
  • Myocardial Contraction / drug effects
  • Myocardial Contraction / physiology
  • Neuropsychological Tests
  • Problem Solving / drug effects*
  • Problem Solving / physiology*
  • Psychomotor Performance / drug effects*
  • Psychomotor Performance / physiology*
  • Reaction Time / drug effects*
  • Reaction Time / physiology*
  • Signal Processing, Computer-Assisted
  • Sleep Deprivation / physiopathology*


  • Chewing Gum
  • Caffeine