Extended longevity mechanisms in short-lived progeroid mice: identification of a preservative stress response associated with successful aging

Mech Ageing Dev. 2007 Jan;128(1):58-63. doi: 10.1016/j.mad.2006.11.011. Epub 2006 Nov 28.


Semantic distinctions between "normal" aging, "pathological" aging (or age-related disease) and "premature" aging (otherwise known as segmental progeria) potentially confound important insights into the nature of each of the complex processes. Here we review a recent, unexpected discovery: the presence of longevity-associated characteristics typical of long-lived endocrine-mutant and dietary-restricted animals in short-lived progeroid mice. These data suggest that a subset of symptoms observed in premature aging, and possibly normal aging as well, may be indirect manifestations of a beneficial adaptive stress response to endogenous oxidative damage, rather than a detrimental result of the damage itself.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Aging / physiology*
  • Animals
  • DNA Repair / physiology
  • Longevity / physiology*
  • Mice
  • Progeria / physiopathology*
  • Stress, Physiological / physiopathology*