Beyond standardization: dynamic software infrastructures for systems biology

Nat Rev Genet. 2007 Mar;8(3):235-43. doi: 10.1038/nrg2048. Epub 2007 Feb 13.


Progress in systems biology is seriously hindered by slow production of suitable software infrastructures. Biologists need infrastructure that easily connects to work that is done in other laboratories, for which standardization is helpful. However, the infrastructure must also accommodate the specifics of their biological system, but appropriate mechanisms to support variation are currently lacking. We argue that a minimal computer language, and a software tool called a generator, can be used to quickly produce customized software infrastructures that 'systems biologists really want to have'.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Databases, Genetic* / trends
  • Humans
  • Software* / trends
  • Systems Biology* / methods
  • Systems Biology* / trends